The Microsoft .NET Desktop Runtime (x64) is a quiet, invisible workhorse of the modern Windows ecosystem. It is not an application you will ever open directly, but without it, many of the applications you rely on daily would be nothing more than files and folders. If you run Windows and install software regularly, having the latest x64 version installed is a best practice for system compatibility.
For more information on the .NET Desktop Runtime x64, please refer to the following resources: microsoft net desktop runtime x64