Updates to either Adobe Acrobat or Microsoft Office can sometimes break the link between the add-in and the framework. How to Fix "Run-time error '53'"
However, this specific file is also the primary source of the notorious that many macOS users encounter when launching Microsoft Office apps. Why Does This Error Occur? Updates to either Adobe Acrobat or Microsoft Office
The error typically triggers because a Microsoft Office application (usually Word or PowerPoint) is trying to load the Adobe PDFMaker add-in, but the required framework file at that specific path is missing, has been moved, or is incompatible with the current version of macOS or the computer's chipset (e.g., Apple M1/M2/M3 chips). Key causes include: The error typically triggers because a Microsoft Office
The MacPDFM.framework is responsible for several background tasks that users interact with indirectly: Quit all Adobe apps
stands for Mac PDF Model (or Mac PDF Manager). It is a proprietary framework developed by Adobe.
Quit all Adobe apps, delete ~/Library/Caches/Adobe/macpdfm/ (cache folder), and restart.