Glucose active transport is technically "secondary" active transport. It doesn't burn ATP (the cell's primary fuel) directly. Instead, it hitches a ride on an established gradient.
GGM is a rare autosomal recessive disorder caused by mutations in the SLC5A1 gene, which encodes SGLT1. Patients present with severe, life-threatening diarrhea in infancy due to the osmotic retention of glucose and galactose in the intestinal lumen. Treatment involves a glucose- and galactose-free diet, substituting fructose (which is absorbed via GLUT5, independent of sodium). glucose active transport
| Parameter | SGLT (Active) | GLUT (Facilitated) | | :--- | :--- | :--- | | | Na⁺ gradient (indirect ATP) | None | | Direction | Against [glucose] gradient | Down [glucose] gradient | | Saturation | Yes (Michaelis-Menten) | Yes | | Inhibition | Phlorizin (specific) | Cytochalasin B | | Na⁺ dependence | Absolute | None | | Concentrating ability | Up to 50x | Cannot concentrate | GGM is a rare autosomal recessive disorder caused