When a virus enters a cell, it may release its genome into the cytoplasm. cGAS detects this viral DNA and begins rapid production of cGAMP.

Once cGAMP levels increase, the molecule acts as a high-affinity ligand for the protein. This binding initiates a signaling cascade that results in:

Here is an informative breakdown of the GAMP levels and what they mean for modern manufacturing.

Enzyme-linked immunosorbent assays (ELISA) provide a more accessible way to detect cGAMP levels in serum or tissue samples, often used in clinical trial settings. Clinical Implications of Dysregulated Levels